Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM50090085'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM50090085(CHEMBL3581532 | US9216988, 37)copy SMILEScopy InChI
Affinity DataIC50: 76nMpH: 7.4Assay Description:On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TB15QCUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM50090085(CHEMBL3581532 | US9216988, 37)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4SPBPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM50090085(CHEMBL3581532 | US9216988, 37)copy SMILEScopy InChI
Affinity DataEC50:  63nMAssay Description:Agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as activa...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4SPBPubMed