Found 19 Enz. Inhib. hit(s) with Target = 'P2Y purinoceptor 14' and Ligand = 'BDBM50456168' TargetP2Y purinoceptor 14(Rattus norvegicus)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Antagonist activity at P2Y14R in rat C6 cells assessed as suppression of UDP-glucose-mediated inhibition of forskolin-stimulated [3H]cyclic-AMP accum...More data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:Antagonist activity at human P2Y14 expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP accumulation incubated for 15 ...More data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Inhibition of mouse P2Y14 receptor in presence of 2% HSAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity human P2Y14R expressed in African green monkey COS7 cells assessed as inhibition of UDPG-induced [3H]inositol phosphate accumulat...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity human P2Y14R expressed in African green monkey COS7 cells assessed as inhibition of UDPG-induced [3H]inositol phosphate accumulat...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo ass...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhib...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of 6-Amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)-naphthalen-1-yl)phenyl)piperidin-1-yl)-butyl)-1H-1,2,...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of 6-Amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)-naphthalen-1-yl)phenyl)piperidin-1-yl)-butyl)-1H-1,2,...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of fluorescent antagonist binding to human P2Y14 expressed in CHO cells incubated for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 m...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 m...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 m...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 3...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-...More data for this Ligand-Target Pair
