BindingDB PrimarySearch

Found 9 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM50403068'

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))TBA

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)copy SMILEScopy InChI

IC50: 1.10nMAssay Description:Inhibition of recombinant human full length His-tagged p110delta/p85alpha expressed in baculovirus expression system measured after 60 mins in presen...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2VX0MBMPubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))TBA

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)copy SMILEScopy InChI

IC50: 1.80nMAssay Description:Inhibition of His-tagged recombinant human PI3K p110delta/p85alpha using lipid substrate incubated for 2 hrs by ADP-Glo assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2RF5ZF7PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))TBA

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)copy SMILEScopy InChI

IC50: 2nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q20R9SR0PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))TBA

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)copy SMILEScopy InChI

IC50: 2.70nMAssay Description:Inhibition of PI3K p110delta/p85alpha (unknown origin) using lipid substrate after 40 mins by kinase-glo luminescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q20G3NMHPubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))TBA

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)copy SMILEScopy InChI

IC50: 3.40nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q28D00WWPubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))TBA

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)copy SMILEScopy InChI

IC50: 17nMAssay Description:Inhibition of PI3KCdelta/PIK3R1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2KS6V81PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))TBA

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)copy SMILEScopy InChI

IC50: 18nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2BV7KNJPubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))TBA

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)copy SMILEScopy InChI

IC50: 19nMAssay Description:Inhibition of His-tagged recombinant human PI3K p110delta/p85alpha expressed in Baculovirus expression systemMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2HD800FPubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))TBA

BDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)copy SMILEScopy InChI

IC50: 25nMAssay Description:Inhibition of his-tagged human recombinant PIK3CD/PIK3R1 by Select-screen kinase inhibitor assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2PG1TPXPubMed PDB

3D Structure (crystal)

Targets 1 ▿
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 9
Publications 7 ▿
- Eur J Med Chem 158: 405-413 (2018) 1
- Bioorg Med Chem Lett 27: 1972-1977 (2017) 1
- Eur J Med Chem 170: 112-125 (2019) 1
- J Med Chem 60: 47-65 (2017) 1
- J Med Chem 63: 441-469 (2020) 1
- J Med Chem 60: 1555-1567 (2017) 1
- J Med Chem 62: 4936-4948 (2019) 1
Institutions 7 ▿
- [INSERM 1052/CNRS 5286/University of Lyon, Gilead Sciences, Inc., Hutchison MediPharma Limited, Xi'an Jiaotong University, Curtin University, University of Arkansas for Medical Sciences, Zhejiang University] 1
- [INSERM 1052/CNRS 5286/University of Lyon, Gilead Sciences, Inc., Hutchison MediPharma Limited, Xi'an Jiaotong University, Curtin University, University of Arkansas for Medical Sciences, Zhejiang University] 1
- [INSERM 1052/CNRS 5286/University of Lyon, Gilead Sciences, Inc., Hutchison MediPharma Limited, Xi'an Jiaotong University, Curtin University, University of Arkansas for Medical Sciences, Zhejiang University] 1
- [INSERM 1052/CNRS 5286/University of Lyon, Gilead Sciences, Inc., Hutchison MediPharma Limited, Xi'an Jiaotong University, Curtin University, University of Arkansas for Medical Sciences, Zhejiang University] 1
- [INSERM 1052/CNRS 5286/University of Lyon, Gilead Sciences, Inc., Hutchison MediPharma Limited, Xi'an Jiaotong University, Curtin University, University of Arkansas for Medical Sciences, Zhejiang University] 1
- [INSERM 1052/CNRS 5286/University of Lyon, Gilead Sciences, Inc., Hutchison MediPharma Limited, Xi'an Jiaotong University, Curtin University, University of Arkansas for Medical Sciences, Zhejiang University] 1
- [INSERM 1052/CNRS 5286/University of Lyon, Gilead Sciences, Inc., Hutchison MediPharma Limited, Xi'an Jiaotong University, Curtin University, University of Arkansas for Medical Sciences, Zhejiang University] 1
Affinity: 1.1 to 25 nM▿
- IC50 9
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1