Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform' and Ligand = 'BDBM50395821'
LigandPNGBDBM50395821(CHEMBL2165191)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445NKMPubMed
LigandPNGBDBM50395821(CHEMBL2165191)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:ATP competitive inhibition of human recombinant PI3Kbeta assessed as PIP3 production by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PG1TPXPubMed
LigandPNGBDBM50395821(CHEMBL2165191)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant PI3Kbeta assessed as PIP3 production by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04F3PubMed
LigandPNGBDBM50395821(CHEMBL2165191)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human PI3Kbeta assessed as reduction in PIP3 formation by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M0CRDPubMed
LigandPNGBDBM50395821(CHEMBL2165191)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human PIK3CB by alphascreen assayMore data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q2HD800FPubMed
LigandPNGBDBM50395821(CHEMBL2165191)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ67PHPubMed