Found 7 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM206061' TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 0.740nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 0.740nMAssay Description:Inhibition of PARP1 (unknown origin) by NAD+ based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
In DepthDetails
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human PARP1 using histone as substrate after 1 hr in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 10nMAssay Description:The HTb-PARP1 positive clones were obtained using the full-length PARP1 plasmid, through PCR amplification, enzyme digestion, ligation, and transform...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 17.3nMAssay Description:Based on the preliminary PARP1 inhibition evaluation of compounds at molecular level by ELISA, compounds were further evaluated for their cellular in...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 20nMAssay Description:The HTb-PARP1 positive clones were obtained using the full-length PARP1 plasmid, through PCR amplification, enzyme digestion, ligation, and transform...More data for this Ligand-Target Pair
