Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM27542'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QPXPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3K12PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of PARP-1 (unknown origin) assessed as incorporation of biotinylated poly ADP-ribose onto histone proteins by colorimetric analysis in pre...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28917DVPubMed