Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM27682'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Pfizer Global R&D--La Jolla Laboratories

Curated by ChEMBL
LigandPNGBDBM27682(5-methyl-1,2,3,4-tetrahydroisoquinolin-1-one | CHE...)copy SMILEScopy InChI
Affinity DataKi:  70nMAssay Description:Inhibition of human Poly (ADP-ribose) polymerase 1 enzymeMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Pfizer Global R&D--La Jolla Laboratories

Curated by ChEMBL
LigandPNGBDBM27682(5-methyl-1,2,3,4-tetrahydroisoquinolin-1-one | CHE...)copy SMILEScopy InChI
Affinity DataIC50: 150nMMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Pfizer Global R&D--La Jolla Laboratories

Curated by ChEMBL
LigandPNGBDBM27682(5-methyl-1,2,3,4-tetrahydroisoquinolin-1-one | CHE...)copy SMILEScopy InChI
Affinity DataIC50: 160nMpH: 8.0 T: 2°CAssay Description:To assess the inhibitory activity of novel inhibitors, the PARP-1 enzyme assay was carried out in reaction mixture consisting of Escherichia coli str...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Pfizer Global R&D--La Jolla Laboratories

Curated by ChEMBL
LigandPNGBDBM27682(5-methyl-1,2,3,4-tetrahydroisoquinolin-1-one | CHE...)copy SMILEScopy InChI
Affinity DataIC50: 420nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Mus musculus)
The University

Curated by ChEMBL
LigandPNGBDBM27682(5-methyl-1,2,3,4-tetrahydroisoquinolin-1-one | CHE...)copy SMILEScopy InChI
Affinity DataIC50: 440nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0FNKPubMed