Compile Data Set for Download or QSAR
Found 17 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2' and Ligand = 'BDBM50005836'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 6.46nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TM7CCDPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NC61X3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP264FPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8NCRPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6DT2PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 6.76nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ052WPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of wild-type human ERG expressed in HEK293 cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M37RKPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 39.8nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8T25PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 39.8nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S7CPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QZ2BGZPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0XT2PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human ERG expressed in CHO cells assessed as whole cell current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN75NTPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibitory activity against Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD12C8PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 98nMAssay Description:Inhibition of human ERG overexpressed in CHO cells by Qpatch methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MG7R9TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Experimental method: hERG patch clamp detection methodExperimental procedure: Compound preparation: the stock solution of a compound was diluted with...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J67M0RUS Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
CASMedChem Laboratory

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:1. CHO-hERG cells which have been incubated overnight were added with sample buffer and incubated for 90 minutes at room temperature in darkness.2. T...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V126X2US Patent