Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50241259'
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)copy SMILEScopy InChI
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase in HEK293 cells expressing APP 695 assessed as reduction in amyloid beta levels after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048X4PubMed
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)copy SMILEScopy InChI
Affinity DataIC50: 0.0820nMAssay Description:Inhibition of gamma secretase in HEK293 cells assessed as reduction in amyloid beta40 level incubated for 4 hrs by electrochemiluminescence detection...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DW9PubMed
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)copy SMILEScopy InChI
Affinity DataIC50: 0.390nMAssay Description:Inhibition of gamma secretase mediated Notch signaling in HEK293 cells after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048X4PubMed
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)copy SMILEScopy InChI
Affinity DataEC50:  0.114nMAssay Description:Reduction of human wild type PS1-induced amyloid beta40 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0456GPubMed
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)copy SMILEScopy InChI
Affinity DataEC50:  0.135nMAssay Description:Reduction of human wild type PS1-induced amyloid beta42 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0456GPubMed