BindingDB PrimarySearch

Found 2 Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50076141'

Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Temple University

Curated by ChEMBL

BDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)copy SMILEScopy InChI

IC50: 200nMAssay Description:Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLSMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

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Details Article
BindingDB Entry DOI: 10.7270/Q2542R5NPubMed

Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Mus musculus)
Yale University

Curated by ChEMBL

BDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)copy SMILEScopy InChI

IC50: 3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Details Article
BindingDB Entry DOI: 10.7270/Q28G8JW7PubMed