Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Protein kinase C alpha type' and Ligand = 'BDBM50107112'
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Displacement of [20-3H]PDBu from recombinant PKC alpha in presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2TQ1PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8R5PPubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]PDBu from mouse recombinant PKCalpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5TQ5PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMpH: 7.4Assay Description:Inhibition of [3H]PDBu binding to recombinant protein kinase C alpha was determined at pH 7.4, 37 degree C for 5 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M07G5PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Binding affinity for Protein kinase C alpha C1a or C1b domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5PJWPubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  402nM ΔG°:  -35.6kJ/molepH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9NQ6PubMed