Found 4 Enz. Inhib. hit(s) with Target = 'Receptor-interacting serine/threonine-protein kinase 1' and Ligand = 'BDBM50159509' TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline
Curated by ChEMBL
GlaxoSmithKline
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline
Curated by ChEMBL
GlaxoSmithKline
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline
Curated by ChEMBL
GlaxoSmithKline
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)-amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline
Curated by ChEMBL
GlaxoSmithKline
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
