Compile Data Set for Download or QSAR
Found 7 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 2' and Ligand = 'BDBM199250'
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)copy SMILEScopy InChI
Affinity DataIC50: 0.450nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571G0RPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z036ZGUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z036ZGUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal GST-tagged ROCK2 (1 to 552) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571G0RPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF029DPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMMore data for this Ligand-Target Pair
In DepthDetails
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z036ZGUS Patent