Compile Data Set for Download or QSAR
Found 14 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 2' and Ligand = 'BDBM322155'
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  105nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25142V2PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
In DepthDetails
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19M2PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8J7NPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 105nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC36F2PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKd:  65nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 10 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1P2HUS Patent