Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 2' and Ligand = 'BDBM322159'
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322159((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  180nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322159((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  180nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322159((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  180nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322159((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 4.64E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322159((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 4.64E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322159((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 4.64E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent