Found 3 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1' and Ligand = 'BDBM50359807' TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Institute of Cancer Research
Curated by ChEMBL
Institute of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Institute of Cancer Research
Curated by ChEMBL
Institute of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Competitive inhibition of human CHK1 using ATP as substrate by DELFIAMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Institute of Cancer Research
Curated by ChEMBL
Institute of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as etoposide-induced G2 check point arrest after 21 hrs by ELISAMore data for this Ligand-Target Pair
