Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PLK1' and Ligand = 'BDBM15234'
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+3nM ΔG°:  -32.9kJ/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8J11PubMedDrugBank
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Inhibition of AX7503 binding to recombinant Plk1 (unknown origin) by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M8XPubMedDrugBank
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-tagged Plk1 using recombinant protein X as a substrate containing threonine residuesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CGPPubMedDrugBank
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PLK1 in the presence of 5uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27082B4PubMedDrugBank