Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase mTOR' and Ligand = 'BDBM50343770'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343770(1-((R)-2,3-Dihydroxypropyl)-3-(4-(7,7-dimethyl-4-(...)copy SMILEScopy InChI
Affinity DataKi:  3.60nMAssay Description:Inhibition of human recombinant mTOR expressed in insect cells using 4E-BP1 substrate after 30 mins by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C6XRHPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343770(1-((R)-2,3-Dihydroxypropyl)-3-(4-(7,7-dimethyl-4-(...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of mTor in human NCI-PC3 cells assessed as inhibition of Akt phosphorylation at serine473 by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C6XRHPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343770(1-((R)-2,3-Dihydroxypropyl)-3-(4-(7,7-dimethyl-4-(...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of mTOR in human NCI-PC3 cells assessed as inhibition of p70S6k phosphorylation by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C6XRHPubMed