BindingDB PrimarySearch

Found 14 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1' and Ligand = 'BDBM2579'

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 2.70nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CV4M86PubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 2.70nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q23J3DWTPubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 4.30nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2DJ5KB8PubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 4.60nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2W380MTPubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 10nMpH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptorsubstrate.More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2222S06PubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 17nMAssay Description:Inhibition of recombinant human GST-tagged PIM1 by ELISAMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q27D2ZSKPubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 22nMAssay Description:Inhibition of Pim1 kinase (unknown origin) using substrate S3 after 50 mins by HTRF assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2XG9T05PubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 31nMAssay Description:Inhibition of recombinant human Pim1 expressed in bacterial expression system using histone H1 as substrate after 30 mins by ADP-Glo reagent based lu...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2HM5C0XPubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 58nMAssay Description:Inhibition of PIM1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2P84FK3PubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 110nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2X63PDVPubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

Kd: 3.20nMAssay Description:Binding constant for PIM1 kinase domainMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q25D8S70PubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

Kd: 15nMAssay Description:Average Binding Constant for PIM1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2V69J3TPubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

Kd: 1.40nMAssay Description:Binding affinity to non phosphorylated PIM1More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2Q52R4HPubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Korea Institute of Science and Technology (KIST)

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

Kd: 3.20nMAssay Description:Binding constant for PIM1 kinase domainMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2TT4RX2PubMed

Targets 1 ▿
- Serine/threonine-protein kinase pim-1 14
Publications 12 ▿
- J Med Chem 52: 3191-204 (2009) 1
- J Med Chem 48: 7604-14 (2005) 1
- Nat Biotechnol 26: 127-32 (2008) 1
- Eur J Med Chem 161: 456-467 (2019) 1
- Eur J Med Chem 141: 657-675 (2017) 1
- J Nat Prod 77: 49-56 (2014) 1
- Bioorg Med Chem 24: 1889-97 (2016) 1
- J Nat Prod 81: 998-1006 (2018) 1
- Eur J Med Chem 154: 101-109 (2018) 1
- Nat Biotechnol 23: 329-36 (2005) 1
- Nat Biotechnol 29: 1046-51 (2011) 1
- J Biol Chem 280: 13728-34 (2005) 1
Institutions 10 ▿
- [Ambit Biosciences] 3
- [Shenyang Pharmaceutical University, Vertex Pharmaceuticals, University of Florida, Heinrich-Heine-Universit£t D£sseldorf , Korea Institute of Science and Technology (KIST), National Cancer Institute, Oxford University, Yunnan University, University of Tours] 1
- [Shenyang Pharmaceutical University, Vertex Pharmaceuticals, University of Florida, Heinrich-Heine-Universit£t D£sseldorf , Korea Institute of Science and Technology (KIST), National Cancer Institute, Oxford University, Yunnan University, University of Tours] 1
- [Shenyang Pharmaceutical University, Vertex Pharmaceuticals, University of Florida, Heinrich-Heine-Universit£t D£sseldorf , Korea Institute of Science and Technology (KIST), National Cancer Institute, Oxford University, Yunnan University, University of Tours] 1
- [Shenyang Pharmaceutical University, Vertex Pharmaceuticals, University of Florida, Heinrich-Heine-Universit£t D£sseldorf , Korea Institute of Science and Technology (KIST), National Cancer Institute, Oxford University, Yunnan University, University of Tours] 1
- [Shenyang Pharmaceutical University, Vertex Pharmaceuticals, University of Florida, Heinrich-Heine-Universit£t D£sseldorf , Korea Institute of Science and Technology (KIST), National Cancer Institute, Oxford University, Yunnan University, University of Tours] 1
- [Shenyang Pharmaceutical University, Vertex Pharmaceuticals, University of Florida, Heinrich-Heine-Universit£t D£sseldorf , Korea Institute of Science and Technology (KIST), National Cancer Institute, Oxford University, Yunnan University, University of Tours] 1
- [Shenyang Pharmaceutical University, Vertex Pharmaceuticals, University of Florida, Heinrich-Heine-Universit£t D£sseldorf , Korea Institute of Science and Technology (KIST), National Cancer Institute, Oxford University, Yunnan University, University of Tours] 1
- [Shenyang Pharmaceutical University, Vertex Pharmaceuticals, University of Florida, Heinrich-Heine-Universit£t D£sseldorf , Korea Institute of Science and Technology (KIST), National Cancer Institute, Oxford University, Yunnan University, University of Tours] 1
- [Shenyang Pharmaceutical University, Vertex Pharmaceuticals, University of Florida, Heinrich-Heine-Universit£t D£sseldorf , Korea Institute of Science and Technology (KIST), National Cancer Institute, Oxford University, Yunnan University, University of Tours] 1
Affinity: 1.4 to 1.1E+2 nM▿
- IC50 10
- Kd 4
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1