Found 20 Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 1' and Ligand = 'BDBM20875' TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of SGLT1 (unknown origin) expressed in HEK293 cells using 2-NBDG as substrate incubated for 30 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 185nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human SGLT1 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 246nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of glucose uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
TargetSodium/glucose cotransporter 1(Rattus norvegicus)
Kissei Pharmaceutical Company
Curated by ChEMBL
Kissei Pharmaceutical Company
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 499nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 536nMAssay Description:Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT1 expressed in african green monkey COS1 cells after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataEC50: 197nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataEC50: 240nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataEC50: 120nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataEC50: 153nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataEC50: 330nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
