Compile Data Set for Download or QSAR
Found 7 Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM20878'
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb Co

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)copy SMILEScopy InChI
Affinity DataKi:  2.40nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F47Q1TPubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb Co

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)copy SMILEScopy InChI
Affinity DataKi:  2.40nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F47Q1TPubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb Co

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)copy SMILEScopy InChI
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB570WPubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb Co

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26111CJPubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb Co

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)copy SMILEScopy InChI
Affinity DataIC50: 6.25nMAssay Description:Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MG7QF6PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb Co

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)copy SMILEScopy InChI
Affinity DataEC50:  9.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5JXGPubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb Co

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)copy SMILEScopy InChI
Affinity DataEC50:  9.20nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN93X4PubMed