Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 2 subunit alpha' and Ligand = 'BDBM50344821'
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Cambridge NeuroScience Inc.

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R49RF5PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90CZDPubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Cambridge NeuroScience Inc.

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIAMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8F39PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of voltage-gated Na channel 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B61GZPubMed