Found 3 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 5 subunit alpha' and Ligand = 'BDBM71064' TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 18.2nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 1 hr in presence of veratridine and anthropleurin-C by sodium influx assayMore data for this Ligand-Target Pair
