Found 5 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM145373' TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 10.6nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 10.6nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
In DepthDetails
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
In DepthDetails
