Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Sodium-dependent noradrenaline transporter' and Ligand = 'BDBM22165'
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)copy SMILEScopy InChI
Affinity DataKi:  138nMAssay Description:NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5WBRUS Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Compound was tested for the inhibition of norepinephrine (NE) reuptakeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5TCPPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of re-uptake of [3H]-NE at human NET expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9ZPVPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN47BSPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1MHHPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M66VBPubMed