BindingDB PrimarySearch

Found 16 Enz. Inhib. hit(s) with Target = 'Sodium-dependent serotonin transporter' and Ligand = 'BDBM22417'

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

Ki: 30nMAssay Description:Invitro competitive binding versus [N-methyl-3H]-WIN 35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2W66K4VPubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

Ki: 54.4nMAssay Description:SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q26D5WBRUS Patent

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Harvard University

Curated by PDSP K_i Database

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

Ki: 158nMMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2ZW1JH0PubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

Ki: 203nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2QJ7GRZPubMed

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Harvard University

Curated by PDSP K_i Database

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

Ki: 277nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2N58N95PubMed

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Harvard University

Curated by PDSP K_i Database

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

Ki: 610nMMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q27H1H2FPubMed

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Harvard University

Curated by PDSP K_i Database

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

Ki: 690nMMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2DV1HCGPubMed

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Harvard University

Curated by PDSP K_i Database

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2DV1HCGPubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

IC50: 20nMAssay Description:Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2MW2JRDPubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

IC50: 277nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2S183C9PubMed

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Harvard University

Curated by PDSP K_i Database

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

IC50: 500nMAssay Description:Binding affinity against serotonin transporter (SERT) by displacement of [3H]paroxetine in male wistar ratsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2QF8TMNPubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

IC50: 700nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q25M66VBPubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

IC50: 700nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2DV1MHHPubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

IC50: 700nMAssay Description:Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2MW2JRDPubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

IC50: 1.40E+3nMAssay Description:Inhibition of serotonin uptake at human SERT in human HEK293 cellsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2T154J4PubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI

IC50: 1.40E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VH5NP8PubMed

Targets 1 ▿
- Sodium-dependent serotonin transporter 16
Publications 14 ▿
- ACS Med Chem Lett 5: 999-1004 (2014) 2
- J Pharmacol Exp Ther 222: 61-5 (1982) 2
- Bioorg Med Chem Lett 18: 4495-8 (2008) 1
- J Med Chem 47: 5258-64 (2004) 1
- Bioorg Med Chem Lett 18: 4224-7 (2008) 1
- Bioorg Med Chem Lett 24: 3234-7 (2014) 1
- J Pharmacol Exp Ther 301: 1097-102 (2002) 1
- Bioorg Med Chem Lett 19: 1164-7 (2009) 1
- Bioorg Med Chem Lett 19: 58-61 (2008) 1
- J Neurochem 44: 1615-22 (1985) 1
- J Med Chem 46: 5512-32 (2003) 1
- J Med Chem 46: 925-35 (2003) 1
- Bioorg Med Chem Lett 18: 4929-31 (2008) 1
- J Med Chem 55: 8188-92 (2012) 1
Institutions 13 ▿
- [Korea University] 3
- [Eli Lilly and Company] 2
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
- [FAES FARMA S A, University of Pennsylvania, Emory University, Neurocrine Biosciences Inc., The State University of New York, Korea Institute of Science and Technology, Harvard University, Schering-Plough Research Institute, Wyeth Research, Lundbeck AIS, Neurocrine Biosciences, Inc.] 1
Affinity: 20 to 1.4E+3 nM▿
- Ki 8
- IC50 8
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1