Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 1' and Ligand = 'BDBM50313320'
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
MERCK SERONO SA

US Patent
LigandPNGBDBM50313320(6-(cyclohexyl(methyl)amino)-N-(4-hydroxyphenyl)pyr...)copy SMILEScopy InChI
Affinity DataKi:  810nM ΔG°:  -32.3kJ/molepH: 7.4 T: 2°CAssay Description:Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H993ZKUS Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
MERCK SERONO SA

US Patent
LigandPNGBDBM50313320(6-(cyclohexyl(methyl)amino)-N-(4-hydroxyphenyl)pyr...)copy SMILEScopy InChI
Affinity DataEC50:  700nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38SQKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
MERCK SERONO SA

US Patent
LigandPNGBDBM50313320(6-(cyclohexyl(methyl)amino)-N-(4-hydroxyphenyl)pyr...)copy SMILEScopy InChI
Affinity DataEC50:  700nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H993ZKUS Patent