Compile Data Set for Download or QSAR
Found 12 Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 4' and Ligand = 'BDBM50192821'
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse TRPV4More data for this Ligand-Target Pair
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by W...More data for this Ligand-Target Pair
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human TRPV4More data for this Ligand-Target Pair
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...More data for this Ligand-Target Pair
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Antagonist activity at TRPV4 (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by W...More data for this Ligand-Target Pair
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 133nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by Who...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 133nMAssay Description:Antagonist activity at rat TRPV4More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50192821(CHEMBL2133556)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...More data for this Ligand-Target Pair