Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Tryptophan 2,3-dioxygenase' and Ligand = 'BDBM309529'
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)copy SMILES
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR22JSPubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)copy SMILES
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GX4F22PubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
Pfizer Inc.; iTEOS THERAPEUTICS

US Patent
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)copy SMILES
Affinity DataIC50: 5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8W03US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)copy SMILES
Affinity DataIC50: 5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8W03US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)copy SMILES
Affinity DataIC50: 1.40E+5nMAssay Description:Inhibition of human TDO2 using tryptophan as substrate after 22 mins by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48M3PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)copy SMILES
Affinity DataIC50: 3.78E+5nMAssay Description:Inhibition of human TDO expressed in human T-REx cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959MV6PubMed