Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 1' and Ligand = 'BDBM50019143'
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50019143(CHEMBL511275 | US10683309, Example LP533401)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9RP0PubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50019143(CHEMBL511275 | US10683309, Example LP533401)copy SMILEScopy InChI
Affinity DataIC50: 583nMAssay Description:Inhibition of Tryptophan hydroxylase 1 (unknown origin) incubated for 4 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J106VMPubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50019143(CHEMBL511275 | US10683309, Example LP533401)copy SMILEScopy InChI
Affinity DataIC50: 2.01E+3nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4TQ6US Patent