Found 25 Enz. Inhib. hit(s) with Target = 'Type-1 angiotensin II receptor' and Ligand = 'BDBM82258' TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
In DepthDetails
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 re...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Displacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 0.330nMAssay Description:Inhibition of angiotensin AT1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 5.62nMAssay Description:Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
In DepthDetails
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 16.2nMAssay Description:Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 16.2nMAssay Description:Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 61.1nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of ATR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 12.6nMAssay Description:Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 6...More data for this Ligand-Target Pair
Affinity DataKd: 12.6nMAssay Description:Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsMore data for this Ligand-Target Pair
Affinity DataKd: 1.58nMAssay Description:In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsMore data for this Ligand-Target Pair
Affinity DataKd: 12.6nMAssay Description:Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post ...More data for this Ligand-Target Pair
Affinity DataKd: 3.72nMAssay Description:pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringsMore data for this Ligand-Target Pair
Affinity DataKd: 200nMAssay Description:Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsMore data for this Ligand-Target Pair
