Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM291635'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck KGaA

Curated by ChEMBL
LigandPNGBDBM291635(1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Covalent inhibition of N-terminal GST-fused human BTK (2-659(end) amino acids) expressed in baculovirus expression system using FITC-AHA-EEPLYWSFPAKK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6TXTPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck KGaA

Curated by ChEMBL
LigandPNGBDBM291635(1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K7C4ZUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck KGaA

Curated by ChEMBL
LigandPNGBDBM291635(1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B95US Patent