Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM147644'
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101W0US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101W0US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3JDHUS Patent