Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM202553'
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)copy SMILEScopy InChI
Affinity DataIC50: 0.127nMAssay Description:A commercial assay by Reaction Biology Corp.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8S22PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)copy SMILEScopy InChI
Affinity DataIC50: 0.130nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK3(Mus musculus)TBA
LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)copy SMILEScopy InChI
Affinity DataIC50: 764nMAssay Description:Inhibition of JAK3 in mouse BaF3 cells assessed as reduction in cell viability by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25142ZDPubMed
TargetTyrosine-protein kinase JAK3(Mus musculus)TBA
LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)copy SMILEScopy InChI
Affinity DataIC50: 790nMAssay Description:Inhibition of JAK3 in mouse BaF3 cells assessed as reduction in cell viability in presence of 0.1 mM H2O2 by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25142ZDPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)copy SMILEScopy InChI
Affinity DataKd:  1.34nMAssay Description:The assay is based on the displacement of a reporter probe by a test compound. Close proximity of the probe and the targeted kinase result in emissio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8S22PubMed