Compile Data Set for Download or QSAR
Found 7 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM50021655'
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z3XPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of JAK3 (unknown origin) using poly(Glu)4Tyr as substrate assessed as 33P incorporation after 20 mins by scintillation counting analysis i...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z3XPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HNDPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3JDHUS Patent
TargetTyrosine-protein kinase JAK3(Mus musculus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of JAK3 in mouse HT-2 clone A5E cells assessed as inhibition of interleukin-2-induced STAT-5 phosphorylation at Y694 preincubated for 1 hr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z3XPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z3XPubMed