BindingDB PrimarySearch

Found 12 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 11' and Ligand = 'BDBM50391109'

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 81nMAssay Description:Inhibition of SHP2 (unknown origin) using pNPP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2KK9G90PubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 2.00E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP2 (catalytic domain 1116 to 2162 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as subst...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2028VWBPubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 7.43E+3nMAssay Description:Inhibition of SHP2 (unknown origin) using 3-o-methylfluorescein phosphate as substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2PK0JP8PubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 7.43E+3nMAssay Description:Inhibition of SHP2 (unknown origin) using 3-o-methylfluorescein phosphate as substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2NP27ZMPubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 1.07E+4nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2BR8WM5PubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 1.16E+4nMAssay Description:Inhibition of SHP2 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 minsMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2QZ2CTVPubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 1.16E+4nMAssay Description:Inhibition of human GST-tagged SHP2 (1116 to 2162 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q23B62P2PubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 1.16E+4nMAssay Description:Inhibition of SHP2 (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q28917N0PubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 1.47E+4nMAssay Description:Inhibition of SHP2 (unknown origin) using pNPP as substrate by spectrophotometryMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q20K2B5MPubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 2.41E+4nMAssay Description:Inhibition of SHP2 (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2CR5XN6PubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 3.47E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2PC3122PubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 2.09E+5nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2MP54XRPubMed

Targets 1 ▿
- Tyrosine-protein phosphatase non-receptor type 11 12
Publications 12 ▿
- Bioorg Med Chem Lett 27: 5154-5157 (2017) 1
- Bioorg Med Chem Lett 30: (2020) 1
- Eur J Med Chem 166: 178-185 (2019) 1
- Bioorg Med Chem Lett 29: 1187-1193 (2019) 1
- Eur J Med Chem 172: 163-173 (2019) 1
- Eur J Med Chem 164: 408-422 (2019) 1
- Bioorg Med Chem 23: 4891-8 (2015) 1
- Eur J Med Chem 144: 692-700 (2018) 1
- Bioorg Med Chem 23: 38-45 (2014) 1
- Bioorg Med Chem Lett 24: 4125-8 (2014) 1
- Bioorg Med Chem 23: 7079-88 (2015) 1
- Bioorg Med Chem Lett 24: 1889-94 (2014) 1
Institutions 9 ▿
- [Jiangnan University] 3
- [Qilu University of Technology] 2
- [Yanbian University, Chinese Academy of Sciences, Qilu University of Technology (Shandong Academy of Sciences), Liaoning Normal University, Yanbian University College of Pharmacy, Nanchang University, Shanghai Jiao Tong University (SJTU)] 1
- [Yanbian University, Chinese Academy of Sciences, Qilu University of Technology (Shandong Academy of Sciences), Liaoning Normal University, Yanbian University College of Pharmacy, Nanchang University, Shanghai Jiao Tong University (SJTU)] 1
- [Yanbian University, Chinese Academy of Sciences, Qilu University of Technology (Shandong Academy of Sciences), Liaoning Normal University, Yanbian University College of Pharmacy, Nanchang University, Shanghai Jiao Tong University (SJTU)] 1
- [Yanbian University, Chinese Academy of Sciences, Qilu University of Technology (Shandong Academy of Sciences), Liaoning Normal University, Yanbian University College of Pharmacy, Nanchang University, Shanghai Jiao Tong University (SJTU)] 1
- [Yanbian University, Chinese Academy of Sciences, Qilu University of Technology (Shandong Academy of Sciences), Liaoning Normal University, Yanbian University College of Pharmacy, Nanchang University, Shanghai Jiao Tong University (SJTU)] 1
- [Yanbian University, Chinese Academy of Sciences, Qilu University of Technology (Shandong Academy of Sciences), Liaoning Normal University, Yanbian University College of Pharmacy, Nanchang University, Shanghai Jiao Tong University (SJTU)] 1
- [Yanbian University, Chinese Academy of Sciences, Qilu University of Technology (Shandong Academy of Sciences), Liaoning Normal University, Yanbian University College of Pharmacy, Nanchang University, Shanghai Jiao Tong University (SJTU)] 1
Affinity: 81 to 2.1E+5 nM▿
- IC50 12
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1