Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 11' and Ligand = 'BDBM50530249'
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530249(CHEMBL4455446 | US10975080, Example 14)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3PZDPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530249(CHEMBL4455446 | US10975080, Example 14)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3PZDPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530249(CHEMBL4455446 | US10975080, Example 14)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TM7F60US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530249(CHEMBL4455446 | US10975080, Example 14)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3PZDPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530249(CHEMBL4455446 | US10975080, Example 14)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3PZDPubMed