Compile Data Set for Download or QSAR
Found 9 Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 1' and Ligand = 'BDBM4621'
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q2F47MBMPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against flt kinaseMore data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q2DR2V2XPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of VEGFR1 phosphorylation in human A498 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69JRBPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of VEGF-induced VEGFR1 phosphorylation in human A498 cells overexpressing Flt-1 pretreated for 60 mins prior to VEGF addition measured aft...More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q25140KNPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of VEGFR1 tyrosine kinase activity in VEGF-stimulated human A498 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6CMNPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of VEGFR1 in human A498 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SX6F6DPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of VEGF-induced VEGFR1 autophosphorylation in human A498 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by pho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8G14PubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q23R0T2ZPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of VEGFR1 (unknown origin) expressed in human tumor cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0T9DPubMed