Compile Data Set for Download or QSAR
Found 18 Enz. Inhib. hit(s) with all data for assayid = 13 entry = 50046453
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113479(CHEMBL3603926 | US10246432, Example 22 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 0.398nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113477(CHEMBL3603924 | US10246432, Example 3 | US10584111...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113473(CHEMBL3603920 | US10246432, Example 1 | US10584111...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113472(CHEMBL3603919 | US10246432, Example 2 | US10584111...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113475(CHEMBL3603922 | US10246432, Example 18 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113478(CHEMBL3603925 | US10246432, Example 20 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113467(CHEMBL3603914 | US10246432, Example 14 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50443085(AFQ056 | Mavoglurant)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113466(CHEMBL3603913 | US10246432, Example 13 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113470(CHEMBL3603917)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113481(CHEMBL3603928)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113469(CHEMBL3603916)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113471(CHEMBL3603918)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113480(CHEMBL3603927 | US10246432, Example 5 | US10584111...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50113341(CHEMBL3603907)copy SMILEScopy InChI
Affinity DataIC50: 398nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70HMZPubMed