Compile Data Set for Download or QSAR
Found 31 Enz. Inhib. hit(s) with all data for assayid = 2 entry = 2522
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21599(2-{5-chloro-1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl...)copy SMILEScopy InChI
Affinity DataKi:  3.80nM EC50:  19nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21595(2-{5-chloro-1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl...)copy SMILEScopy InChI
Affinity DataKi:  5.30nM EC50:  23nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21610(2-[(3R)-5-chloro-1'-[(5-chloro-2-fluorophenyl)meth...)copy SMILEScopy InChI
Affinity DataKi:  5.30nM EC50:  66nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21594(2-{5-chloro-1'-[(5-methyl-3-phenyl-1,2-oxazol-4-yl...)copy SMILEScopy InChI
Affinity DataKi:  7.60nM EC50:  21nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21579(2-{5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-1...)copy SMILEScopy InChI
Affinity DataKi:  10nM EC50:  48nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21605(2-[(3R)-5-chloro-1'-[(3-chlorophenyl)methyl]-1,2-d...)copy SMILEScopy InChI
Affinity DataKi:  23nM EC50:  107nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21585(2-(5-chloro-1'-{[2-(3-chlorophenyl)-1,3-thiazol-4-...)copy SMILEScopy InChI
Affinity DataKi:  24nM EC50:  48nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21574(2-{5-chloro-1'-[(2,3-difluorophenyl)methyl]-1,2-di...)copy SMILEScopy InChI
Affinity DataKi:  25nM EC50:  296nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21580(2-{5-chloro-1'-[(3,5-dichlorophenyl)methyl]-1,2-di...)copy SMILEScopy InChI
Affinity DataKi:  36nM EC50:  82nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21584(2-{5-chloro-1'-[(2-methyl-1,3-thiazol-4-yl)methyl]...)copy SMILEScopy InChI
Affinity DataKi:  38nM EC50:  236nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21593(2-{5-chloro-1'-[(3,5-dimethyl-1,2-oxazol-4-yl)meth...)copy SMILEScopy InChI
Affinity DataKi:  51nM EC50:  220nMAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21569(2-{5-chloro-1'-[(4-chlorophenyl)methyl]-1,2-dihydr...)copy SMILEScopy InChI
Affinity DataKi:  115nM ΔG°:  -39.2kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Mus musculus (mouse))
Merck Serono

LigandPNGBDBM21543(2-{1'-benzyl-5-chloro-1,2-dihydrospiro[indole-3,3'...)copy SMILEScopy InChI
Affinity DataKi:  150nM ΔG°:  -38.6kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21563(2-[5-chloro-1'-(2-phenylethyl)-1,2-dihydrospiro[in...)copy SMILEScopy InChI
Affinity DataKi:  267nM ΔG°:  -37.1kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21565(2-[5-chloro-1'-(1-phenylethyl)-1,2-dihydrospiro[in...)copy SMILEScopy InChI
Affinity DataKi:  356nM ΔG°:  -36.4kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21545(2-{1'-benzyl-5-fluoro-1,2-dihydrospiro[indole-3,3'...)copy SMILEScopy InChI
Affinity DataKi:  712nM ΔG°:  -34.7kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21564(2-{5-chloro-1'-[(2E)-3-phenylprop-2-en-1-yl]-1,2-d...)copy SMILEScopy InChI
Affinity DataKi:  747nM ΔG°:  -34.6kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21550(4-[5-chloro-1'-(prop-2-en-1-yl)-1,2-dihydrospiro[i...)copy SMILEScopy InChI
Affinity DataKi:  769nM ΔG°:  -34.5kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21560(4-{5-chloro-1'-[(4-methoxyphenyl)methyl]-1,2-dihyd...)copy SMILEScopy InChI
Affinity DataKi:  960nM ΔG°:  -34.0kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21553(2-[5-chloro-1'-(2-methoxyethyl)-1,2-dihydrospiro[i...)copy SMILEScopy InChI
Affinity DataKi:  1.45E+3nM ΔG°:  -33.0kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21554(4-{1'-benzyl-5-chloro-1,2-dihydrospiro[indole-3,3'...)copy SMILEScopy InChI
Affinity DataKi:  1.66E+3nM ΔG°:  -32.7kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21546(2-{1'-benzyl-5-methoxy-1,2-dihydrospiro[indole-3,3...)copy SMILEScopy InChI
Affinity DataKi:  2.74E+3nM ΔG°:  -31.4kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21549(2-{5-fluoro-1'-[(2-methoxyethoxy)methyl]-1,2-dihyd...)copy SMILEScopy InChI
Affinity DataKi:  3.83E+3nM ΔG°:  -30.6kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21556(4-[5-fluoro-1'-(prop-2-en-1-yl)-1,2-dihydrospiro[i...)copy SMILEScopy InChI
Affinity DataKi:  4.13E+3nM ΔG°:  -30.4kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21557(4-{1'-benzyl-5-fluoro-1,2-dihydrospiro[indole-3,3'...)copy SMILEScopy InChI
Affinity DataKi:  4.17E+3nM ΔG°:  -30.4kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21548(2-{5-chloro-1'-[(dimethylcarbamoyl)methyl]-1,2-dih...)copy SMILEScopy InChI
Affinity DataKi:  4.67E+3nM ΔG°:  -30.1kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21552(2-{5-chloro-1'-methyl-1,2-dihydrospiro[indole-3,3'...)copy SMILEScopy InChI
Affinity DataKi:  7.62E+3nM ΔG°:  -28.9kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21555(4-{5-fluoro-1'-methyl-1,2-dihydrospiro[indole-3,3'...)copy SMILEScopy InChI
Affinity DataKi:  8.90E+3nM ΔG°:  -28.5kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21551(1'-benzyl-5-chloro-1-methyl-1,2-dihydrospiro[indol...)copy SMILEScopy InChI
Affinity DataKi:  1.16E+4nM ΔG°:  -27.9kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21547(2-{1'-[(dimethylcarbamoyl)methyl]-5-fluoro-1,2-dih...)copy SMILEScopy InChI
Affinity DataKi: >3.00E+4nM ΔG°: >-25.6kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

LigandPNGBDBM21558(Spiro-indolinone analogue, 51 | ethyl 2-{1'-benzyl...)copy SMILEScopy InChI
Affinity DataKi: >3.00E+4nM ΔG°: >-25.6kJ/molepH: 7.4 T: 2°CAssay Description:A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PZSPubMed