Compile Data Set for Download or QSAR
Found 24 Enz. Inhib. hit(s) with all data for assayid = 2 entry = 50027437
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50275934((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50276015(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50275935((S)-2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-...)copy SMILEScopy InChI
Affinity DataKi:  9nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50275358((2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyr...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50276065((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50276018(1-(3-(cyclopenta-1,3-dienyl)benzyl)-3,5-diethylben...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50249284(2-(4-methyl-2-(2-(3-methyl-5-(trifluoromethyl)phen...)copy SMILEScopy InChI
Affinity DataKi:  22nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50275357(CHEMBL451450 | N-(3-methoxy-5-(trifluoromethyl)phe...)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50276064(CHEMBL470780 | N-(3,5-dimethylphenyl)-4-(5-methylt...)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50249286(3-(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trif...)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50276016(CHEMBL512319 | N-(3-methoxy-5-(trifluoromethyl)phe...)copy SMILEScopy InChI
Affinity DataKi:  28nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50249318(2-(2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4...)copy SMILEScopy InChI
Affinity DataKi:  32nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50275355((2-(2-(3-methoxy-5-(trifluoromethyl)phenylamino)py...)copy SMILEScopy InChI
Affinity DataKi:  33nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50276017(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trifluo...)copy SMILEScopy InChI
Affinity DataKi:  44nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50275356(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50249356(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)copy SMILEScopy InChI
Affinity DataKi:  56nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50276063(4-(thiazol-2-yl)-N-m-tolylpyrimidin-2-amine | CHEM...)copy SMILEScopy InChI
Affinity DataKi:  82nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50249416(CHEMBL471776 | N-(3-methyl-5-(trifluoromethyl)phen...)copy SMILEScopy InChI
Affinity DataKi:  110nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50249540((R)-2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-...)copy SMILEScopy InChI
Affinity DataKi:  210nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50249226(CHEMBL513985 | N-(3-phenoxyphenyl)-4-(thiazol-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  630nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50249258(CHEMBL475570 | N-(2,5-dimethylphenyl)-4-(thiazol-2...)copy SMILEScopy InChI
Affinity DataKi:  1.82E+3nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50275976(3-((5-methoxy-1-methylindolin-3-yl)methylene)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50275977(CHEMBL512345 | N1-(3-(4-morpholinophenyl)isoquinol...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed