Compile Data Set for Download or QSAR
Found 201 of ic50 for UniProtKB: P22909
LigandPNGBDBM50225293(CHEBI:5553 | Guanabenz | WY-8678)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50226942(CHEMBL39286)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NC63FNPubMed
LigandPNGBDBM50226153(CHEMBL545092)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5W7DPubMed
LigandPNGBDBM34572(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
LigandPNGBDBM50295557(7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:The compound was evaluated for the alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidineMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NC63FNPubMed
LigandPNGBDBM50001922(2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM30712(6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
LigandPNGBDBM50225247(CHEMBL44558)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM50226155(CHEMBL543684)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5W7DPubMed
LigandPNGBDBM50070193(1-((6aR,9R,10aR)-2-tert-Butyl-7-methyl-4,6,6a,7,8,...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M61JF3PubMed
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2 adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25H7JFFPubMed
LigandPNGBDBM50048608(CHEMBL154488 | Indol-1-yl-pyridin-4-yl-amine)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8R7KPubMed
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21V5H5WPubMed
LigandPNGBDBM50225292(HOE-440 | Symcor Base TTS | Tiamenidine)copy SMILEScopy InChI
Affinity DataIC50: 9.10nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)copy SMILEScopy InChI
Affinity DataIC50: 9.10nMAssay Description:Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SQ92M9PubMed
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SQ92M9PubMed
LigandPNGBDBM50225294(CHEMBL146100)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Binding affinity against alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50225288(Tramazoline)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50225290(CHEMBL146419)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]-clonidine to alpha-2-adrenoceptor.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25H7JFFPubMed
LigandPNGBDBM50225235(CHEMBL42909)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM30703(2-(4-tert-butyl-2,6-dimethyl-benzyl)-2-imidazoline...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50048589(CHEMBL152842 | Indol-1-yl-methyl-pyridin-4-yl-amin...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8R7KPubMed
LigandPNGBDBM86053(B-HT 920 | CAS_101626-70-4 | CHEMBL279085 | NSC_10...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50225241(CHEMBL42242)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM96559(2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50029051((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5W7DPubMed
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]-clonidine to alpha-2-adrenoceptor.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25H7JFFPubMed
LigandPNGBDBM50225248(CHEMBL42309)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in rat brain using [3H]- clonidineMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2319TVFPubMed
LigandPNGBDBM50017543((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2-adrenoceptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25H7JFFPubMed
LigandPNGBDBM392076(US10301272, Example 7/9)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Displacement of [3H]-RX 821002 from rat alpha2 adrenoceptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6FPCPubMed
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2-adrenoceptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25H7JFFPubMed
LigandPNGBDBM50226156(CHEMBL544627)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5W7DPubMed
LigandPNGBDBM50225250(CHEMBL42237)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM50225251(CHEMBL295359)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]-clonidine binding (0.4 nM) to rat isolated brain mem...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM50225234(CHEMBL41980)copy SMILEScopy InChI
Affinity DataIC50: 71nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM50067212(CHEBI:8093 | Cyclomydril | Duo-Medihaler | Phenyle...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against Alpha-2 adrenergic receptor in rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4S4VPubMed
LigandPNGBDBM50070186(1-Acetyl-3-((6aR,9S,10aR)-7-methyl-4,6,6a,7,8,9,10...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M61JF3PubMed
LigandPNGBDBM50026553((+)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50225243(CHEMBL41420)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NT8PubMed
LigandPNGBDBM85091((+/-)-2-DIPROPYLAMINO- 6,7-DIHYDROXY-1,2,3,4-TETRA...)copy SMILEScopy InChI
Affinity DataIC50: 87nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B31WHPubMed
LigandPNGBDBM50070188(1-((6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,...)copy SMILEScopy InChI
Affinity DataIC50: 87nMAssay Description:Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M61JF3PubMed
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