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TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157445(3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{3-[(2,...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157461(3-{4-[(3,5-Dichloro-pyridine-4-carbonyl)-amino]-ph...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157458(3-{4-[(3,5-Dichloro-pyridine-4-carbonyl)-amino]-ph...)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157446(3-{4-[(3,5-Dichloro-pyridine-4-carbonyl)-amino]-ph...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMAssay Description:Inhibitory activity against I-Eotaxin binding to human CCR3 receptorsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098643(1-((E)-1-Cyclooct-1-enyl)methyl-4-[(2,7-dichloro-9...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMAssay Description:Concentration required for 50% inhibition of [125I]-Eotaxin binding to human CCR3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FDCPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157464(3-{4-[(3,5-Dichloro-pyridine-4-carbonyl)-amino]-ph...)copy SMILEScopy InChI
Affinity DataIC50: 0.650nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)copy SMILEScopy InChI
Affinity DataIC50: 0.730nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098643(1-((E)-1-Cyclooct-1-enyl)methyl-4-[(2,7-dichloro-9...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Concentration required for 50% inhibition of [125I]-Eotaxin binding to human CCR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FDCPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157470(3-{4-[(3,5-Dichloro-pyridine-4-carbonyl)-amino]-ph...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157475(3-{4-[(3,5-Dichloro-pyridine-4-carbonyl)-amino]-ph...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098636(1-Cyclooct-1-enylmethyl-4-[(2,7-dibromo-9H-xanthen...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157447(3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{3-[(2,...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM18161((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]testosterone from androgen receptor in Sprague-Dawley rat prostate gland after 2 hrs by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098641(1-Cyclooct-1-enylmethyl-1-ethyl-4-[(9H-xanthene-9-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099482(2-(6-Amino-benzothiazol-2-ylsulfanyl)-N-[1-(3,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Concentration required for 50% inhibition of [125I]-Eotaxin binding to human CCR3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FDCPubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098651(1-Cyclooct-1-enylmethyl-1-methyl-4-[(9H-xanthene-9...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM109264(US8609710, 40)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5DPPUS Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098628(1-Cyclooct-1-enylmethyl-1-propyl-4-[(9H-xanthene-9...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM18161((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Competitive binding affinity to rat androgen receptorChecked by AuthorMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098633(1-Cyclooctylmethyl-4-[(2,7-dibromo-9H-xanthene-9-c...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157459(3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{3-[(2,...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM18161((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Displacement of [3H]testosterone from Sprague-Dawley rat AR by liquid scintillation countingMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098648(1-Cyclooctylmethyl-4-[(2,7-dibromo-9H-xanthene-9-c...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098637(1-Cyclooctylmethyl-1-propyl-4-[(9H-xanthene-9-carb...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157469(3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{3-[(2,...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098627(1-Cyclooctylmethyl-4-[(2,7-dibromo-9H-xanthene-9-c...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM326336((1R*,2S*)-2-(3-Aminopropyl)-1-[1-(3,3-dimethylbuty...)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:HEPES buffered saline (20 mM HEPES, 150 mM NaCl, pH 7.4; hereinafter, referred to as HBS) was used in the preparation of a reaction solution. To 12 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W09829US Patent
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157466(3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{3-[(2,...)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098642(1-Butyl-1-cyclooctylmethyl-4-[(9H-xanthene-9-carbo...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50338693(2-methyl-2-((3aR,4S,9bS)-8-nitro-3a,4,5,9b-tetrahy...)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Competitive binding affinity to rat androgen receptorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3MKZPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM109265(US8609710, 35 (2S,4R form))copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5DPPUS Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098626(1-Cyclooctylmethyl-1-ethyl-4-[(9H-xanthene-9-carbo...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM109258(US8609710, 34 (2S,4S form))copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5DPPUS Patent
TargetC-C chemokine receptor type 1(Mus musculus)
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Inhibitory activity against 125 I -MIP-1 alpha binding to mouse CCR1 receptorsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetC-C chemokine receptor type 1(Mus musculus)
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetProgesterone receptor(Oryctolagus cuniculus)
Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3MKZPubMed
TargetProgesterone receptor(Oryctolagus cuniculus)
Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]progesterone from rabbit PR by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474B55PubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)copy SMILEScopy InChI
Affinity DataIC50: 6.10nMAssay Description:Inhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73D0GPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM109254(US8609710, 25)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5DPPUS Patent
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM109256(US8609710, 33)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5DPPUS Patent
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM109252(US8609710, 15 (2S form))copy SMILEScopy InChI
Affinity DataIC50: 7.80nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5DPPUS Patent
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM326397((1R,2S)-2-[(2R)-2-(Aminomethyl)butyl]-1-(1-phenyl-...)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:HEPES buffered saline (20 mM HEPES, 150 mM NaCl, pH 7.4; hereinafter, referred to as HBS) was used in the preparation of a reaction solution. To 12 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W09829US Patent
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM109253(US8609710, 24)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5DPPUS Patent
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM326395((1R,2S)-2-[(2R)-2-(Aminomethyl)butyl]-1-(1-pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:HEPES buffered saline (20 mM HEPES, 150 mM NaCl, pH 7.4; hereinafter, referred to as HBS) was used in the preparation of a reaction solution. To 12 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W09829US Patent
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM109238(US8609710, 2)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5DPPUS Patent
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Kaken Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157463(3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{3-[(2,...)copy SMILEScopy InChI
Affinity DataIC50: 8.40nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27945Z1PubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM326336((1R*,2S*)-2-(3-Aminopropyl)-1-[1-(3,3-dimethylbuty...)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMAssay Description:HEPES buffered saline (20 mM HEPES, 150 mM NaCl, pH 7.4; hereinafter, referred to as HBS) was used in the preparation of a reaction solution. To 12 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W09829US Patent
TargetCarboxypeptidase B2(Homo sapiens (Human))
Daiichi Sankyo Company, Limited

US Patent
LigandPNGBDBM326393((1R,2S)-2-[(2R)-3-Amino-2-methylpropyl]-1-[1-(5-me...)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMAssay Description:HEPES buffered saline (20 mM HEPES, 150 mM NaCl, pH 7.4; hereinafter, referred to as HBS) was used in the preparation of a reaction solution. To 12 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W09829US Patent
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