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Tyrosine-protein kinase Srms(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL

BDBM50135286(CHEMBL3745885)copy SMILEScopy InChI

IC50: 1.00E+4nMAssay Description:Inhibition of human SRMS using poly[Glu:Tyr] (4:1) as substrateMore data for this Ligand-Target Pair

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Details Article
BindingDB Entry DOI: 10.7270/Q24Q7WT8PubMed

Targets 329 ▿
- Serine/threonine-protein kinase PLK2 7
- Serine/threonine-protein kinase PLK1 2
- TGF-beta receptor type-1 2
- Serine/threonine-protein kinase PLK3 2
- Serine/threonine-protein kinase PLK4 2
- cGMP-dependent protein kinase 1 2
- Tyrosine-protein kinase Lyn 2
- Cyclin-dependent kinase 5 activator 1 2
- Serine/threonine-protein kinase haspin 1
- Tyrosine-protein kinase Tec 1
- Tyrosine-protein kinase JAK1 1
- Rhodopsin kinase GRK1 1
- LIM domain kinase 1 1
- LIM domain kinase 2 1
- ALK tyrosine kinase receptor 1
- NUAK family SNF1-like kinase 2 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Calcium/calmodulin-dependent protein kinase type 1 1
- Protein kinase C iota type 1
- NUAK family SNF1-like kinase 1 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1
- Serine/threonine-protein kinase PAK 1 1
- Protein kinase C theta type 1
- Serine/threonine-protein kinase PAK 2 1
- Serine/threonine-protein kinase PAK 3 1
- Dual specificity mitogen-activated protein kinase kinase 2 1
- Serine/threonine-protein kinase PAK 4 1
- Serine/threonine-protein kinase tousled-like 2 1
- Dual specificity mitogen-activated protein kinase kinase 3 1
- Serine/threonine-protein kinase PAK 5 1
- Serine/threonine-protein kinase PAK 6 1
- Serine/threonine-protein kinase tousled-like 1 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Dual specificity mitogen-activated protein kinase kinase 4 1
- Tyrosine-protein kinase ZAP-70 1
- Leucine-rich repeat serine/threonine-protein kinase 2 1
- Serine/threonine-protein kinase Sgk2 1
- Serine/threonine-protein kinase Sgk1 1
- Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 1
- Casein kinase I isoform gamma-3 1
- Casein kinase I isoform gamma-2 1
- Serine/threonine-protein kinase Sgk3 1
- Casein kinase I isoform epsilon 1
- Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 1
- Casein kinase I isoform gamma-1 1
- Myosin light chain kinase 3 1
- Ephrin type-A receptor 1 1
- Ephrin type-A receptor 3 1
- Ephrin type-A receptor 2 1
- Ephrin type-A receptor 5 1
- Tyrosine-protein kinase BTK 1
- Ephrin type-A receptor 4 1
- Ephrin type-A receptor 7 1
- Ephrin type-A receptor 6 1
- Tyrosine-protein kinase receptor UFO 1
- Insulin-like growth factor 1 receptor 1
- Cyclin-A2/Cyclin-dependent kinase 2 1
- Myosin light chain kinase 2, skeletal/cardiac muscle 1
- Tyrosine-protein kinase Srms 1
- Wee1-like protein kinase 1
- Focal adhesion kinase 1 1
- Lymphokine-activated killer T-cell-originated protein kinase 1
- Cyclin-dependent kinase/G1/S-specific cyclin- 1 1
- Cyclin-K 1
- Tyrosine-protein kinase TXK 1
- Rhodopsin kinase GRK7 1
- Ephrin type-A receptor 8 1
- Death-associated protein kinase 2 1
- Death-associated protein kinase 1 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D3 1
- TGF-beta receptor type-2 1
- Serine/threonine-protein kinase D1 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1
- Dual serine/threonine and tyrosine protein kinase 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Death-associated protein kinase 3 1
- Serine/threonine-protein kinase pim-3 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase pim-2 1
- Serine/threonine-protein kinase 38 1
- Testis-specific serine/threonine-protein kinase 1 1
- Protein kinase C epsilon type 1
- Testis-specific serine/threonine-protein kinase 2 1
- Bone morphogenetic protein receptor type-2 1
- Protein-tyrosine kinase 6 1
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 1
- Testis-specific serine/threonine-protein kinase 6 1
- Casein kinase II subunit alpha 1
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 1
- Testis-specific serine/threonine-protein kinase 3 1
- Leukocyte tyrosine kinase receptor 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- Tyrosine-protein kinase ABL2 1
- Tyrosine-protein kinase ABL1 1
- Serine/threonine-protein kinase A-Raf 1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 1
- Rho-associated protein kinase 2 1
- Rho-associated protein kinase 1 1
- Serine/threonine-protein kinase ULK1 1
- Serine/threonine-protein kinase SIK2 1
- Tyrosine-protein kinase Fes/Fps 1
- Serine/threonine-protein kinase SIK1 1
- Serine/threonine-protein kinase ULK2 1
- Serine/threonine-protein kinase ULK3 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Mitogen-activated protein kinase 1 1
- Serine/threonine-protein kinase 3 1
- Mitogen-activated protein kinase 3 1
- Discoidin domain-containing receptor 2 1
- Serine/threonine-protein kinase 4 1
- SRSF protein kinase 3 1
- Mitogen-activated protein kinase 9 1
- SRSF protein kinase 2 1
- Mitogen-activated protein kinase 7 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Mitogen-activated protein kinase 8 1
- Tyrosine-protein kinase SYK 1
- Serine/threonine-protein kinase TBK1 1
- Serine/threonine-protein kinase LATS1 1
- Tau-tubulin kinase 1 1
- Serine/threonine-protein kinase 32B 1
- Cyclin-H/Cyclin-dependent kinase 7 1
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 1
- Cell division cycle 7-related protein kinase/Protein DBF4 homolog A 1
- Tau-tubulin kinase 2 1
- Serine/threonine-protein kinase 32C 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Tyrosine-protein kinase HCK 1
- Vascular endothelial growth factor receptor 3 1
- Vascular endothelial growth factor receptor 1 1
- Insulin receptor-related protein 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Tyrosine-protein kinase receptor TYRO3 1
- Serine/threonine-protein kinase BRSK1 1
- Serine/threonine-protein kinase LATS2 1
- Protein kinase C gamma type 1
- Platelet-derived growth factor receptor alpha 1
- Serine/threonine-protein kinase BRSK2 1
- Protein kinase C zeta type 1
- Serine/threonine-protein kinase Chk2 1
- Serine/threonine-protein kinase Chk1 1
- cAMP-dependent protein kinase catalytic subunit PRKX 1
- SRSF protein kinase 1 1
- Tyrosine-protein kinase Yes 1
- Serine/threonine-protein kinase WNK1 1
- Serine/threonine-protein kinase MRCK beta 1
- Serine/threonine-protein kinase MRCK gamma 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 4 1
- Casein kinase II subunit alpha' 1
- Serine/threonine-protein kinase WNK3 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 1
- Serine/threonine-protein kinase STK11 1
- Serine/threonine-protein kinase WNK2 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 3 1
- Receptor tyrosine-protein kinase erbB-4 1
- Receptor tyrosine-protein kinase erbB-2 1
- Tyrosine-protein kinase FRK 1
- Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 1
- Hepatocyte growth factor receptor 1
- Serine/threonine-protein kinase B-raf 1
- Serine/threonine-protein kinase Nek9 1
- Serine/threonine-protein kinase Nek7 1
- Glycogen synthase kinase-3 alpha 1
- Serine/threonine-protein kinase Nek6 1
- Serine/threonine-protein kinase Nek5 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek3 1
- Serine/threonine-protein kinase Nek2 1
- Serine/threonine-protein kinase receptor R3 1
- Serine/threonine-protein kinase Nek1 1
- Macrophage-stimulating protein receptor 1
- Serine/threonine-protein kinase SIK3 [59-1321] 1
- MAP/microtubule affinity-regulating kinase 3 1
- Homeodomain-interacting protein kinase 4 1
- Homeodomain-interacting protein kinase 3 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- MAP kinase-interacting serine/threonine-protein kinase 1 1
- Serine/threonine-protein kinase 10 1
- MAP/microtubule affinity-regulating kinase 4 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Serine/threonine-protein kinase 38-like 1
- Myosin-IIIb 1
- Serine/threonine-protein kinase Nek11 1
- Cyclin-A1/Cyclin-dependent kinase 2 1
- Tyrosine-protein kinase ITK/TSK 1
- Myotonin-protein kinase 1
- Protein kinase C eta type 1
- Bone morphogenetic protein receptor type-1A 1
- Tyrosine-protein kinase Blk 1
- Serine/threonine-protein kinase 16 1
- Receptor-interacting serine/threonine-protein kinase 2 1
- Epidermal growth factor receptor 1
- Non-receptor tyrosine-protein kinase TNK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Receptor-interacting serine/threonine-protein kinase 3 1
- Serine/threonine-protein kinase NLK 1
- Homeodomain-interacting protein kinase 2 1
- Homeodomain-interacting protein kinase 1 1
- Ribosomal protein S6 kinase beta-2 1
- Ribosomal protein S6 kinase beta-1 1
- Serine/threonine-protein kinase OSR1 1
- Casein kinase I isoform delta 1
- Protein kinase C beta type 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Serine/threonine-protein kinase 26 1
- Serine/threonine-protein kinase 24 1
- Serine/threonine-protein kinase 25 1
- Dual specificity testis-specific protein kinase 1 1
- Ephrin type-B receptor 3 1
- Serine/threonine-protein kinase 33 1
- Ephrin type-B receptor 4 1
- Ephrin type-B receptor 1 1
- cAMP-dependent protein kinase catalytic subunit gamma 1
- Ephrin type-B receptor 2 1
- Activated CDC42 kinase 1 1
- MAP kinase-activated protein kinase 2 1
- MAP kinase-activated protein kinase 3 1
- Platelet-derived growth factor receptor beta 1
- Epithelial discoidin domain-containing receptor 1 1
- MAP kinase-activated protein kinase 5 1
- STE20/SPS1-related proline-alanine-rich protein kinase 1
- Muscle, skeletal receptor tyrosine-protein kinase 1
- Tyrosine-protein kinase Fer 1
- Calcium/calmodulin-dependent protein kinase type II subunit delta 1
- PAS domain-containing serine/threonine-protein kinase 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Beta-adrenergic receptor kinase 2 1
- Beta-adrenergic receptor kinase 1 1
- Serine/threonine-protein kinase TAO1 1
- Serine/threonine-protein kinase DCLK1 1
- Calcium/calmodulin-dependent protein kinase kinase 1 1
- Serine/threonine-protein kinase DCLK2 1
- Serine/threonine-protein kinase TAO3 1
- Calcium/calmodulin-dependent protein kinase kinase 2 1
- Serine/threonine-protein kinase TAO2 1
- Angiopoietin-1 receptor 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Mitogen-activated protein kinase kinase kinase kinase 3 1
- Mast/stem cell growth factor receptor Kit 1
- Mitogen-activated protein kinase kinase kinase kinase 1 1
- Serine/threonine-protein kinase MRCK alpha 1
- Mitogen-activated protein kinase kinase kinase kinase 4 1
- Mitogen-activated protein kinase kinase kinase kinase 5 1
- Mitogen-activated protein kinase 15 1
- Interleukin-1 receptor-associated kinase 4 1
- Mitogen-activated protein kinase kinase kinase 9 1
- Serine/threonine-protein kinase VRK1 1
- Serine/threonine-protein kinase VRK2 1
- RAC-gamma serine/threonine-protein kinase 1
- Mitogen-activated protein kinase kinase kinase 5 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 8 1
- Mitogen-activated protein kinase kinase kinase 7 1
- Mitogen-activated protein kinase kinase kinase 2 1
- Mitogen-activated protein kinase kinase kinase 1 1
- Mitogen-activated protein kinase kinase kinase 3 1
- Serine/threonine-protein kinase ICK 1
- RAC-alpha serine/threonine-protein kinase 1
- Megakaryocyte-associated tyrosine-protein kinase 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Myosin light chain kinase, smooth muscle 1
- BDNF/NT-3 growth factors receptor 1
- Serine/threonine-protein kinase 17A 1
- Tyrosine-protein kinase Lck 1
- Dual specificity protein kinase CLK1 1
- Protein kinase C delta type 1
- NT-3 growth factor receptor 1
- G protein-coupled receptor kinase 5 1
- G protein-coupled receptor kinase 4 1
- Dual specificity protein kinase CLK4 1
- Dual specificity protein kinase CLK3 1
- Dual specificity protein kinase CLK2 1
- High affinity nerve growth factor receptor 1
- G protein-coupled receptor kinase 6 1
- Protein-tyrosine kinase 2-beta 1
- Tyrosine-protein kinase Mer 1
- Serine/threonine-protein kinase N2 1
- Protein kinase C-binding protein 1 1
- cAMP-dependent protein kinase catalytic subunit beta 1
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 1
- Serine/threonine-protein kinase N3 1
- Serine/threonine-protein kinase N1 1
- Ribosomal protein S6 kinase alpha-2 1
- Ribosomal protein S6 kinase alpha-3 1
- Calcium/calmodulin-dependent protein kinase type 1B 1
- Ribosomal protein S6 kinase alpha-1 1
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1
- Calcium/calmodulin-dependent protein kinase type 1D 1
- STE20-like serine/threonine-protein kinase 1
- Calcium/calmodulin-dependent protein kinase type 1G 1
- Fibroblast growth factor receptor 4 1
- Tyrosine-protein kinase Fgr 1
- Aurora kinase B 1
- Aurora kinase A 1
- Mitogen-activated protein kinase kinase kinase 20 1
- Fibroblast growth factor receptor 1 1
- Fibroblast growth factor receptor 2 1
- Fibroblast growth factor receptor 3 1
- Aurora kinase C 1
- Mitogen-activated protein kinase 13 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Mitogen-activated protein kinase 12 1
- Mitogen-activated protein kinase 11 1
- RAC-beta serine/threonine-protein kinase 1
- Mitogen-activated protein kinase 10 1
- Casein kinase I isoform alpha 1
- Misshapen-like kinase 1 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Macrophage colony-stimulating factor 1 receptor 1
- Ribosomal protein S6 kinase alpha-6 1
- Protein kinase C alpha type 1
- Ribosomal protein S6 kinase alpha-4 1
- Maternal embryonic leucine zipper kinase 1
- Ribosomal protein S6 kinase alpha-5 1
- Serine/threonine-protein kinase MARK1 1
- Serine/threonine-protein kinase MARK2 1
- TRAF2 and NCK-interacting protein kinase 1
- Mitogen-activated protein kinase kinase kinase 12 1
- Mitogen-activated protein kinase kinase kinase 10 1
- Mitogen-activated protein kinase kinase kinase 11 1
Publications 1 ▿
- Bioorg Med Chem 24: 521-44 (2016) 342
Institutions 1 ▿
- [Icahn School of Medicine at Mount Sinai] 342
Affinity: 3.1E+2 to 1.0E+4 nM▿
- IC50 342
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1