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Affinity DataIC50: 2.60nMAssay Description:Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellu...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellu...More data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
AstraZeneca
Curated by ChEMBL
AstraZeneca
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of Zn2+-induced intracellular calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13.4nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 14.5nMAssay Description:Displacement of [3H]AZD9272 from mGluR5 in Sprague-Dawley rat striatum by autoradiographic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:The cDNA for the soluble part of the human 13-Secretase (AA 1-AA 460) was cloned using the ASP2-Fc10-1-IRES-GFP-neoK mammalian expression vector. The...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:The cDNA for the soluble part of the human 13-Secretase (AA 1-AA 460) was cloned using the ASP2-Fc10-1-IRES-GFP-neoK mammalian expression vector. The...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Displacement of [3H]AZD9272 from mGluR5 in Sprague-Dawley rat striatum by autoradiographic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of glutamate-stimulated ...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:The cDNA for the soluble part of the human 13-Secretase (AA 1-AA 460) was cloned using the ASP2-Fc10-1-IRES-GFP-neoK mammalian expression vector. The...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of glutamate-stimulated ...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 57nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:The cDNA for the soluble part of the human 13-Secretase (AA 1-AA 460) was cloned using the ASP2-Fc10-1-IRES-GFP-neoK mammalian expression vector. The...More data for this Ligand-Target Pair
Affinity DataIC50: 74nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 74nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 75nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 77nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 79nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 81nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 84nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 91nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 97nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
