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TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288677(US10087191, Example 94)copy SMILES
Affinity DataIC50: 0.0400nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288659(US10087191, Example 74)copy SMILEScopy InChI
Affinity DataIC50: 0.210nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288672((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.210nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288680(US10087191, Example 97)copy SMILEScopy InChI
Affinity DataIC50: 0.240nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288611( (E)-3-(4-((1S,3R)-6-(1-(difluoromethyl)-1H-pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 0.290nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288653(US10087191, Example 68)copy SMILEScopy InChI
Affinity DataIC50: 0.310nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288605((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288616(US10087191, Example 21)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288643(US10087191, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 0.330nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288673((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288675((E)-3-(3,5-difluoro-4-((6S,8R/6R,8S)-(7-isobutyl-8...)copy SMILES
Affinity DataIC50: 0.430nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288658((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-5-fluoro-2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 0.450nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288619(US10087191, Example 25)copy SMILES
Affinity DataIC50: 0.510nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288684((E)-3-(4-((6R,8R/6S,8S)-7-isobutyl-8-methyl-6,7,8,...)copy SMILES
Affinity DataIC50: 0.640nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288608((E)-3-(3,5-difluoro-4-((1S,3R)-2-(2-fluoro-2-methy...)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288601((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288602((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.730nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288656(US10087191, Example 71)copy SMILEScopy InChI
Affinity DataIC50: 0.740nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288436((E)-3-(3,5-difluoro-4-((5S,7R/5R,7S)-6-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.770nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288655((E)-3-(3,5-difluoro-4-((6S,8R/6R,8S)-7-(2-fluoro-2...)copy SMILES
Affinity DataIC50: 0.770nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288642((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.820nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288644((E)-3-(4-((1S,3R/1R,3S)-6-(1-cyclopropyl-1H-pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 0.840nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288681(US10087191, Example 98)copy SMILEScopy InChI
Affinity DataIC50: 0.850nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288615((E)-3-(4-((1S,3R/1R,3S)-6-(1-ethyl-1H-pyrazol -4-y...)copy SMILEScopy InChI
Affinity DataIC50: 0.860nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288633((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-5-fluoro-2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 0.870nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288650(US10087191, Example 64)copy SMILEScopy InChI
Affinity DataIC50: 1.07nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288613((E)-3-(4-((1S,3R/1R,3S)-6-(1-ethyl-1H-pyrazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.17nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288671((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)copy SMILES
Affinity DataIC50: 1.22nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288603((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.25nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288607((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.26nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288685((E)-3-(4-((6S,8R/6R,8S)-7-cyclopentyl-8-methyl-6,7...)copy SMILES
Affinity DataIC50: 1.32nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288612((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-7-fluoro-2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 1.36nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288660((E)-3-(4-((1R,3R/1S,3S)-6-(1-ethyl-1H-pyrazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.39nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288623((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.45nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288635((E)-3-(4-((1S,3R/1R,3S)-6-(1-ethyl-1H-pyrazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288614((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.52nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288618((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILES
Affinity DataIC50: 1.59nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288649((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288636((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.82nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288606(US10087191, Example 8)copy SMILEScopy InChI
Affinity DataIC50: 1.85nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288674((E)-3-(3,5-difluoro-4-((5S,7R/5R,7S)-6-(2-fluoro-2...)copy SMILES
Affinity DataIC50: 1.88nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288630((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.94nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288610((E)-3-(4-((1S,3R/1R,3S)-(6-(1-(difluoromethyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 2.11nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288621((E)-3-(3,5-difluoro-4-((1S,3R/1R,3 S)-2-(2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 2.28nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288661((E)-3-(3,5-difluoro-4-((6S,8R/6R,8S)-7-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 2.47nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288667((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-8-fluoro-2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 2.97nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288683((E)-3-(4-((6S,8R/6R,8S)-7-(2-fluoro-2-methylpropyl...)copy SMILES
Affinity DataIC50: 3.14nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288600((E)-3-(3,5-difluoro-4-((6S,8R/6R,8S)-7-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288651((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.25nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM288637((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP04T1US Patent
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