Compile Data Set for Download or QSAR
Found 775 with your filter
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081273((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.520nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081256((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081259((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.620nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081265((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.860nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081246((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081252((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50139763(CHEMBL306657 | [(E)-(9S,10S,14S,18S)-18-Carbamoylm...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity of the compound was determined in in surface plasmon resonance (SPR) methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2668CNNPubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50139763(CHEMBL306657 | [(E)-(9S,10S,14S,18S)-18-Carbamoylm...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity of the compound was determined in in surface plasmon resonance (SPR) methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2668CNNPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081240(2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazolin-6...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354621(3-(6-{4-[(4-Hydroxyphenyl)(methyl)carbamoyl]-1,5-d...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081243(2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazolin-6...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081260((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 1.62nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354602(4-[2-(Dimethylamino)ethoxy]phenyl 6-{4-[(4-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081261((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081247((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081239((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354648((1r,4r)-4-{[(tert-Butoxy)carbonyl]amino}cyclohexyl...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50222495((S)-1-(2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phen...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of ErbB2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9PTZPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50222489((R)-N-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)pheny...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9PTZPubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50139763(CHEMBL306657 | [(E)-(9S,10S,14S,18S)-18-Carbamoylm...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:In vitro binding affinity in extracellular ELISA-based assay for Grb2 SH2 domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD114QPubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354597(2-[2-(Dimethylamino)ethoxy]phenyl 6-{4-[(4-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081253((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081272((S)-5-Acetylsulfamoyl-2-{4-[(2,7-dimethyl-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354624(3-[2-(Dimethylcarbamoyl)ethyl]phenyl 6-{4-[(4-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354619(3-(6-{4-[(4-Hydroxyphenyl)(methyl)carbamoyl]-1,5-d...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM352978(3-{2-[2-(4-Cyanophenyl)acetyl]-7-[(3R)-3-methyl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081264((S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetThymidylate synthase(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50081249(2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazolin-6...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64XDPubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354593(Phenyl 6-{4-[(4-hydroxyphenyl)(methyl)carbamoyl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354623(2-[2-(Dimethylcarbamoyl)ethyl]phenyl 6-{4-[(4-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM353045(4-Fluorophenyl 6-{1-[(4-hydroxyphenyl)(methyl)carb...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354612(4-Methylphenyl 6-{1,5-dimethyl-4-[methyl(phenyl)ca...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354588(Phenyl 6-{4-[(4-hydroxyphenyl)(propyl)carbamoyl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM353042(N,1,2-trimethyl-5-{7-[(3S)-3-(morpholin-4-ylmethyl...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM353047(4-Chlorophenyl 6-{1-[(4-hydroxyphenyl)(methyl)carb...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM353026(N-(4-Hydroxyphenyl)-5-{2-[2-(4-methoxyphenyl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354629(N-(4-Hydroxyphenyl)-1,2-dimethyl-5-{7-[(3S)-3-(mor...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354649((1r,4r)-4-Aminocyclohexyl 6-{4-[(4-hydroxyphenyl)(...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354592(Phenyl 6-{4-[(4-hydroxyphenyl)(methyl)carbamoyl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM353033(3-{2-[2-(4-{[2-(Dimethylamino)ethyl]amino}phenyl)a...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354656(Phenyl 6-{4-[(4-hydroxyphenyl)(methyl)carbamoyl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354556(4-Cyanophenyl 6-{4-[(4-hydroxyphenyl)(methyl)carba...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354639(Cyclohexyl 6-{4-[(4-hydroxyphenyl)(methyl)carbamoy...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354627(N-(4-Hydroxyphenyl)-N,1,2-trimethyl-5-{7-[(3S)-3-[...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354598(3-[2-(Dimethylamino)ethoxy]phenyl 6-{4-[(4-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM352993(Phenyl 6-{4-[(4-hydroxyphenyl)(methyl)carbamoyl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354594(N-Butyl-N-(4-hydroxyphenyl)-1,2-dimethyl-5-{7-[(3S...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM353046(4-Methoxyphenyl 6-{1-[(4-hydroxyphenyl)(methyl)car...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354558(4-Cyano-2-methoxyphenyl 6-{1-[(4-hydroxyphenyl)(me...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent
LigandPNGBDBM354589(Phenyl 6-{4-[butyl(4-hydroxyphenyl)carbamoyl]-1,5-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP55DFUS Patent
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