Compile Data Set for Download or QSAR
Found 34 of ic50 data for polymerid = 2178
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327527(2-(4-bromophenyl)-N-((7-methoxy-2-(pyridin-4-yl)qu...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327528(2-(4-bromophenyl)-N-((7-methoxy-2-(pyridin-3-yl)qu...)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327516(2-(4-bromophenyl)-N-((7-methoxy-2-(thiophen-3-yl)q...)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327540(3-((4-bromophenethylamino)methyl)-2-(thiophen-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 82nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50003407(CHEMBL3234568)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41SZ3PubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327521(2-(4-chlorophenyl)-N-((7-methoxy-2-(thiophen-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 97nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM21679((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-e...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50003573(CHEMBL3234871)copy SMILEScopy InChI
Affinity DataIC50: 215nMAssay Description:Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41SZ3PubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)copy SMILEScopy InChI
Affinity DataIC50: 251nMAssay Description:Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125VJ1PubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327541(3-((4-bromophenethylamino)methyl)-7-methoxy-2-(thi...)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327526(2-(4-bromophenyl)-N-((7-methoxy-2-phenylquinolin-3...)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327525(2-(4-bromophenyl)-N-((2-(furan-2-yl)-7-methoxyquin...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327520(CHEMBL1258310 | N-(4-chlorobenzyl)-1-(7-methoxy-2-...)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327523(2-(4-bromophenyl)-N-((7-methoxy-2-(thiophen-2-yl)q...)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327524(2-(4-bromophenyl)-N-((2-(furan-3-yl)-7-methoxyquin...)copy SMILEScopy InChI
Affinity DataIC50: 710nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327518(1-(7-methoxy-2-(thiophen-3-yl)quinolin-3-yl)-N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 880nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327519(1-(7-methoxy-2-(thiophen-3-yl)quinolin-3-yl)-N-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327531(2-(4-bromophenyl)-N-((7-methoxy-2-(oxazol-2-yl)qui...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327522(2-(3-bromophenyl)-N-((7-methoxy-2-(thiophen-3-yl)q...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327534(2-(4-bromophenyl)-N-((7-ethoxy-2-(thiophen-3-yl)qu...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327532(2-(4-bromophenyl)-N-((7-methyl-2-(thiophen-3-yl)qu...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327530(2-(4-bromophenyl)-N-((7-methoxy-2-(thiazol-2-yl)qu...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327538(3-((4-bromophenethylamino)methyl)-2-(thiophen-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 5.10E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327537(2-(4-bromophenyl)-N-((2-(thiophen-3-yl)quinolin-3-...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM21680((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R,16S)-5,9,1...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327533(2-(4-bromophenyl)-N-((7-chloro-2-(thiophen-3-yl)qu...)copy SMILEScopy InChI
Affinity DataIC50: 6.90E+3nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327544(3-((4-bromophenethylamino)methyl)-2-(thiophen-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327539(2-(4-bromophenyl)-N-((6-methoxy-2-(thiophen-3-yl)q...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327535(2-(4-bromophenyl)-N-((2-(thiophen-3-yl)-7-(trifluo...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327529(2-(4-bromophenyl)-N-((7-methoxy-2-(pyridin-3-yloxy...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327536(3-((4-bromophenethylamino)methyl)-2-(thiophen-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327542(2-(4-bromophenyl)-N-((6,7-dimethoxy-2-(thiophen-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327543(3-((4-bromophenethylamino)methyl)-6-methoxy-2-(thi...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys, Inc.

Curated by ChEMBL
LigandPNGBDBM50327517(CHEMBL1258081 | N-benzyl-1-(7-methoxy-2-(thiophen-...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87B1HPubMed