TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Compound was tested for inhibition of human activated protein C (APC)More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Compound was tested for inhibition of human activated protein C (APC)More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Compound was tested for inhibition of human activated protein C (APC)More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 670nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 710nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 820nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 870nMAssay Description:Compound was tested for inhibition of human activated protein C (APC)More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 920nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 980nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assayMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
Affinity DataIC50: 3.51E+3nMAssay Description:Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Tested in vitro for the inhibitory activity against activated protein C (APC)More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assayMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 3.83E+3nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.53E+3nMAssay Description:Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibitory activity against activated protein C (aPC)More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 6.56E+3nMAssay Description:Inhibitory activity of the compound against activated protein C (APC)More data for this Ligand-Target Pair
Affinity DataIC50: 6.71E+3nMAssay Description:Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.55E+3nMAssay Description:Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.56E+3nMAssay Description:Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.95E+3nMAssay Description:Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assayMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Institut de Recherches Servier
Curated by ChEMBL
Institut de Recherches Servier
Curated by ChEMBL
Affinity DataIC50: 9.08E+3nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair