Found 493 of ic50 data for polymerid = 3022 TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 14.5nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 35.7nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 40.7nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 49.6nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 50.1nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 53.5nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 54.5nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 57nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 81nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 93nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
3D Structure (crystal)TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant AKR1C2 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant AKR1C2 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 370nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 370nMAssay Description:Inhibition of AKR1C2 by fluorimetric methodMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 370nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 380nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 440nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 440nMAssay Description:Inhibition of AKR1C2 by fluorimetric methodMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 440nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 510nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 530nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 530nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 540nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 610nMAssay Description:Inhibition of recombinant human AKR1C2 using S-tetralol as substrateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 630nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 870nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 910nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 910nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 920nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 970nMAssay Description:Inhibition of recombinant human AKR1C2 using S-tetralol as substrateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 980nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Vanderbilt University; The Trustees of the University of Pennsylvania
US Patent
Affinity DataIC50: 1.26E+3nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
